Parameters

Chlorzoxazone

BCG

Treatment groups

RPMP

DBR

MIX

AUC(0 − t) (mg* h/l)

28.46 ± 5.21

12.66 ± 4.12^**

13.98 ± 5.75^**

17.30 ± 2.67^**

AUC(0 −∞) (mg* h/l)

39.95 ± 19.56

13.31 ± 4.64^**▲

16.88 ± 4.57^*

17.40 ± 2.67^**

MRT(0 − t) (h)

2.64 ± 0.62

1.47 ± 0.79^**

1.96 ± 0.77^▲

0.98 ± 0.34^**

MRT(0 −∞) (h)

9.36 ± 10.51

2.06 ± 1.28

8.19 ± 5.32^▲▲

1.03 ± 0.42

t_1/2 (h)

9.65 ± 2.95

2.67 ± 1.71^**

6.14 ± 1.94^*▲

3.84 ± 0.41^**

CL (l/h/kg)

0.46 ± 0.16

1.32 ± 0.43^**▲

1.01 ± 0.27^**

0.94 ± 0.13^**

Vz (L/Kg)

5.25 ± 1.90

4.55 ± 2.57^▲▲

7.15 ± 2.48^▲▲

1.14 ± 0.55^**